Liu Shuqiong, He Zhihang, Xu Guojie, Xiao Xiufeng
College of Chemistry and Chemical Engineering, Fujian Normal University, Fujian, Fuzhou 350007, China; Ecology and Resource Engineering, Wuyi University, Fujian, Nanping, Wuyishan 354300, China.
College of Chemistry and Chemical Engineering, Fujian Normal University, Fujian, Fuzhou 350007, China.
Mater Sci Eng C Mater Biol Appl. 2014 Nov;44:201-8. doi: 10.1016/j.msec.2014.08.012. Epub 2014 Aug 10.
Three-dimensional polycaprolactone (PCL) scaffolds with spherulite and nanofibrous structures were fabricated for the first time by thermally induced phase separation from a ternary PCL/dioxane/water system. Moreover, the effects of polymer concentration, aging temperature and the ratio of dioxane to water on the morphology of nanofibrous scaffolds were investigated. The result revealed that gelation, aging temperature, and ratio of solvents significantly influenced the formation of the unique spherulite and nanofibrous structures. The apatite-formation ability test showed relatively rapid growth of carbonate hydroxyapatite in the nanofibrous PCL scaffold with macropore compared to the other two scaffolds with smooth structure and nanofibrous structure without macropore, respectively, indicating good apatite-formation ability of the macroporous and nanofibrous PCL scaffolds.
首次通过热诱导相分离从三元聚己内酯/二氧六环/水体系制备了具有球晶和纳米纤维结构的三维聚己内酯（PCL）支架。此外，研究了聚合物浓度、老化温度以及二氧六环与水的比例对纳米纤维支架形态的影响。结果表明，凝胶化、老化温度和溶剂比例显著影响独特的球晶和纳米纤维结构的形成。磷灰石形成能力测试表明，与另外两种分别具有光滑结构和无大孔纳米纤维结构的支架相比，具有大孔的纳米纤维PCL支架中碳酸羟基磷灰石的生长相对较快，这表明大孔和纳米纤维PCL支架具有良好的磷灰石形成能力。
