Östlund Papadogeorgos Nikolaos, Jörneskog Gun, Bengtsson Mattias, Kahan Thomas, Kalani Majid
Dept of Cardiology, Danderyd University Hospital Corp, 182 88, Stockholm, Sweden.
Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
Cardiovasc Diabetol. 2016 Apr 20;15:66. doi: 10.1186/s12933-016-0385-6.
Microvascular function is impaired in patients with stable coronary artery disease. The aim was to study microvascular function in patients with diabetes and acute coronary syndrome (ACS).
Microvascular function was evaluated in 83 patients by laser Doppler fluxmetry (LDF) [PU; perfusion unit, median (interquartile range)] measuring resting LDF and peak LDF following a six min heating of the skin to 44 °C at the foot, respectively. All patients with ACS and without previously known diabetes underwent oral glucose tolerance test. Thirty-nine patients with type 2 diabetes mellitus free from coronary artery disease served as controls.
Peak LDF was significantly (P = 0.03) lower in patients with ACS and diabetes (n = 22; 72 (52)) and diabetes without coronary artery disease (n = 39; 69 (51)) as compared to patients with ACS without diabetes (n = 46; 97 (60)), and patients without ACS (n = 15; 140 (121)), respectively. Patients with ACS (n = 68) had significantly (P = 0.04) lower peak LDF (92 (49)) as compared to patients without ACS (n = 15) (140 (121)).
Microvascular reactivity is severely impaired in patients with diabetes and ACS. Diabetes has a major influence on microvascular function in patients with coronary artery disease.
稳定型冠状动脉疾病患者的微血管功能受损。本研究旨在探讨糖尿病合并急性冠状动脉综合征（ACS）患者的微血管功能。
采用激光多普勒血流仪（LDF）[PU；灌注单位，中位数（四分位间距）]对83例患者的微血管功能进行评估，分别测量足部皮肤在加热至44°C持续6分钟后的静息LDF和峰值LDF。所有ACS患者且既往无糖尿病史者均接受口服葡萄糖耐量试验。39例无冠状动脉疾病的2型糖尿病患者作为对照。
与无糖尿病的ACS患者（n = 46；97（60））和无ACS患者（n = 15；140（121））相比，ACS合并糖尿病患者（n = 22；72（52））和无冠状动脉疾病的糖尿病患者（n = 39；69（51））的峰值LDF显著降低（P = 0.03）。与无ACS患者（n = 15）（140（121））相比，ACS患者（n = 68）的峰值LDF显著降低（P = 0.04）（92（49））。
糖尿病合并ACS患者的微血管反应性严重受损。糖尿病对冠状动脉疾病患者的微血管功能有重大影响。
