构建冠状病毒以评估其出现及致病潜力。
Engineering Coronaviruses to Evaluate Emergence and Pathogenic Potential.
作者信息
Lau Susanna K P, Woo Patrick C Y
机构信息
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Department of Microbiology, The University of Hong Kong, Hong Kong, China; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310006, China.
出版信息
Trends Microbiol. 2016 Jun;24(6):427-429. doi: 10.1016/j.tim.2016.04.001. Epub 2016 Apr 16.
A recent study provides a platform for generating infectious coronavirus genomes using sequence data, examining their capabilities of replicating in human cells and causing diseases in animal models, and evaluating therapeutics and vaccines. Similar approaches could be used to assess the potential of human emergence and pathogenicity for other viruses.
最近的一项研究提供了一个平台，可利用序列数据生成具有传染性的冠状病毒基因组，研究它们在人类细胞中复制以及在动物模型中引发疾病的能力，并评估治疗方法和疫苗。类似的方法可用于评估其他病毒出现并导致人类发病的可能性。
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