中国南方动物中与严重急性呼吸综合征冠状病毒相关病毒的分离与鉴定

Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China.

作者信息

Guan Y, Zheng B J, He Y Q, Liu X L, Zhuang Z X, Cheung C L, Luo S W, Li P H, Zhang L J, Guan Y J, Butt K M, Wong K L, Chan K W, Lim W, Shortridge K F, Yuen K Y, Peiris J S M, Poon L L M

机构信息

Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China.

出版信息

Science. 2003 Oct 10;302(5643):276-8. doi: 10.1126/science.1087139. Epub 2003 Sep 4.

DOI:10.1126/science.1087139

PMID:12958366

Abstract

A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.

摘要

一种新型冠状病毒（SCoV）是严重急性呼吸综合征（SARS）的病原体。在中国广东一个活体动物市场发现的果子狸体内分离出了类似SCoV的病毒。在其他动物（包括貉，Nyctereutes procyonoides）以及在同一市场工作的人员中也检测到了病毒感染的证据。所有动物分离株都保留了一段29个核苷酸的序列，而大多数人类分离株中未发现该序列。在一个零售市场的小型活体野生哺乳动物中检测到类似SCoV的病毒，这表明存在种间传播途径，尽管其自然宿主尚不清楚。