Radomska-Leśniewska Dorota M, Skopińska-Różewska Ewa, Demkow Urszula, Jóźwiak Jarosław, Sobiecka Małgorzata, Bałan Barbara Joanna
Department of Histology and Embryology, Biostructure Centre, Medical University of Warsaw, Warsaw, Poland.
Department of Pathomorphology, Biostructure Centre, Medical University of Warsaw, Warsaw, Poland; Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
Cent Eur J Immunol. 2016;41(1):25-34. doi: 10.5114/ceji.2016.58311. Epub 2016 Mar 24.
Sarcoidosis is a systemic inflammatory disease with abnormally high angiogenic activity of inflammatory cells. Reumaherb preparation consisting of three herbs: Echinacea purpurea, Harpagophytum procumbens, and Filipendula ulmaria, and it exerts anti-inflammatory, antioxidant, and analgesic activity and stimulates regenerative and immunological processes. The aim of this paper was to estimate the effect of Reumaherb on immunological angiogenesis induced by bronchoalveolar lavage (BAL) cells collected from six patients with sarcoidosis and grafted into Balb/c mice skin. After grafting, the animals were fed for three days with 0.6 or 1.2 mg of Reumaherb (calculated from recommended human daily dose) daily, suspended in 40 µl of water, or 40 µl of water alone (control group). A significant reduction of newly formed blood vessels was obtained in four cases for 1.2 mg and in three cases for 0.6 mg daily dose of this remedy. Thus, we hypothesise that Reumaherb promotes anti-angiogenic activity and may potentially be used in diseases associated with excessive blood vessel formation.
结节病是一种全身性炎症性疾病，炎症细胞具有异常高的血管生成活性。Reumaherb制剂由三种草药组成：紫锥菊、钩果草和绣线菊，具有抗炎、抗氧化和镇痛活性，并能刺激再生和免疫过程。本文的目的是评估Reumaherb对从六例结节病患者收集的支气管肺泡灌洗（BAL）细胞诱导并移植到Balb/c小鼠皮肤中的免疫性血管生成的影响。移植后，给动物连续三天每天喂食0.6或1.2毫克Reumaherb（根据推荐的人类每日剂量计算），悬浮于40微升水中，或仅喂食40微升水（对照组）。对于该药物，每日剂量为1.2毫克时，有四例新形成血管显著减少；每日剂量为0.6毫克时，有三例新形成血管显著减少。因此，我们推测Reumaherb具有促进抗血管生成活性的作用，可能可用于与血管过度形成相关的疾病。
