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一种改善阻塞性睡眠呼吸暂停患者持续气道正压通气(PAP)依从性的适应性治疗:一项概念验证试验

An Adaptive Treatment to Improve Positive Airway Pressure (PAP) Adherence in Patients With Obstructive Sleep Apnea: A Proof of Concept Trial.

作者信息

Cvengros Jamie A, Rodríguez Vivian M, Snyder Sarah, Hood Megan M, Crawford Megan, Park Margaret

机构信息

a Rush Sleep Disorders Service and Research Center , Rush University Medical Center , Chicago , Illinois.

b Department of Psychiatry and Behavioral Sciences , Memorial Sloan-Kettering Cancer Center , New York , New York.

出版信息

Behav Sleep Med. 2017 Sep-Oct;15(5):345-360. doi: 10.1080/15402002.2015.1135292. Epub 2016 Apr 20.

DOI:10.1080/15402002.2015.1135292
PMID:27096396
Abstract

Despite the benefits of positive airway pressure (PAP) treatment, rates of adherence to treatment are suboptimal. This proof-of-concept study assessed the feasibility, acceptability, and clinical significance of an adaptive treatment strategy to improve adherence to PAP. All participants first completed a brief educational intervention. Those who did not show at least a 25% increase in PAP use were randomized to receive a second, more intensive intervention, either motivational enhancement treatment or self-management treatment. Results suggested adequate feasibility and acceptability. In addition, participants demonstrated significant increases in objective PAP use, improvements in sleep quality, and decreases in daytime sleepiness. This study represents a first step in the development and validation of an adaptive treatment strategy to improve PAP adherence.

摘要

尽管气道正压通气(PAP)治疗有诸多益处,但治疗依从率仍不尽人意。这项概念验证研究评估了一种适应性治疗策略在提高PAP治疗依从性方面的可行性、可接受性及临床意义。所有参与者首先完成了一次简短的教育干预。那些PAP使用量未至少增加25%的参与者被随机分配接受第二种更强化的干预措施,即动机增强治疗或自我管理治疗。结果表明该策略具有足够的可行性和可接受性。此外,参与者在客观的PAP使用量上有显著增加,睡眠质量得到改善,日间嗜睡情况减少。这项研究是开发和验证一种提高PAP依从性的适应性治疗策略的第一步。

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