Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Cabrera Felipe s/n, 35016 Las Palmas de Gran Canaria, Spain; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERObn), Paseo Blas Cabrera Felipe s/n, 35016 Las Palmas de Gran Canaria, Spain.
Internal Medicine Service, Faculty of Veterinary Medicine, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe s/n, 35016 Las Palmas de Gran Canaria, Spain.
Sci Total Environ. 2016 Aug 15;562:128-135. doi: 10.1016/j.scitotenv.2016.03.204. Epub 2016 Apr 17.
Persistent organochlorine pollutants (POPs) are toxic chemicals, which accumulate in humans and animals, as only few species have the capability of eliminating them. However, some authors have pointed to the possibility that certain species of invertebrates (i.e. nematodes) could metabolize this type of compounds. As certain species of nematodes act as parasites of vertebrates, this research was designed to explore the influence of some of the most common parasites of the dogs in their serum levels of 56 common POPs. The study included three groups of dogs (n=64), which were prospectively recruited in the island of Gran Canaria (Canary Islands, Spain): a) control animals, non-parasitized (serologically tested negative, n=24); b) dogs tested positive for intestinal parasites and negative for other parasites (n=24); and c) dogs tested positive for heartworm disease (Dirofilaria immitis) and negative for other parasites (n=16). The presence of Dirofilaria immitis was strongly associated with lower serum levels of a wide range of pollutant in their hosts (PCB congeners 28, 52, 118, 138, 153, and 180; hexachlorobenzene, lindane, aldrin, dieldrin, anthracene and pyrene). We also found an inverse association between the hosts' serum levels of PCBs and intestinal parasites. We did not find any association with DDT or its metabolites, but this might be explained by the recently suggested ability of dogs for the efficient metabolization of these compounds. According to the results of this study certain forms of parasitism would reduce the bioavailability of the major classes of POPs in dogs. However, further studies are needed to elucidate whether this phenomenon is due to a competence between parasites and hosts or could respond to a possible capability of parasitic nematodes for the metabolization of these POPs.
持久性有机污染物 (POPs) 是有毒化学物质，它们在人类和动物体内积累，因为只有少数物种具有消除它们的能力。然而，一些作者指出，某些无脊椎动物（即线虫）可能会代谢这种类型的化合物。由于某些线虫物种是脊椎动物的寄生虫，因此这项研究旨在探索一些最常见的犬寄生虫对其血清中 56 种常见 POP 水平的影响。该研究包括在西班牙加那利群岛的大加那利岛（Gran Canaria）前瞻性招募的三组犬（n=64）：a）对照动物，未感染寄生虫（血清学检测阴性，n=24）；b）肠道寄生虫检测呈阳性但其他寄生虫检测呈阴性的犬（n=24）；c）心丝虫病（犬恶丝虫）检测呈阳性但其他寄生虫检测呈阴性的犬（n=16）。犬恶丝虫的存在与宿主体内多种污染物血清水平降低密切相关（多氯联苯同系物 28、52、118、138、153 和 180；六氯苯、林丹、艾氏剂、狄氏剂、蒽和芘）。我们还发现宿主血清中多氯联苯水平与肠道寄生虫之间存在负相关关系。我们没有发现与滴滴涕或其代谢物有关的任何关联，但这可能是由于最近提出的狗有效代谢这些化合物的能力。根据这项研究的结果，某些形式的寄生虫感染会降低犬体内主要类别的 POP 的生物利用度。然而，需要进一步的研究来阐明这种现象是由于寄生虫和宿主之间的竞争还是可能是由于寄生线虫代谢这些 POP 的能力。
