Monti J P, Gallice P, Baz M, Murisasco A, Crevat A, Elsen R
Laboratoire de Biophysique, Faculté de Pharmacie, Marseille, France.
Kidney Int. 1989 Mar;35(3):871-4. doi: 10.1038/ki.1989.66.
Before hemodialysis, patients have an intraerythrocytic pH (pHi) and an extracellular pH, measured in whole blood (pHo), which are lower than those of healthy controls. During bicarbonate hemodialysis, pHi values continuously increase, approaching a normal value at the end of the session. Concomitantly, pHo values follow similar variations. During acetate hemodialysis, pHi values exhibit a steep initial decrease, reaching a minimum after about 15 minutes. Concurrently, however, pHo values decrease only slightly. This phenomenon seems to originate in the intraerythrocytic medium and might be due to a shift in intracellular CO2/bicarbonate equilibrium. This drop in pHi exhibits interpatient variability, suggesting that the magnitude of pH decrease would be correlated with the degree of the problems observed in some patients undergoing acetate hemodialysis.
血液透析前，患者的红细胞内pH值（pHi）和全血测量的细胞外pH值（pHo）低于健康对照者。在碳酸氢盐血液透析过程中，pHi值持续升高，在透析结束时接近正常值。同时，pHo值也有类似变化。在醋酸盐血液透析过程中，pHi值最初急剧下降，约15分钟后降至最低。然而，与此同时，pHo值仅略有下降。这种现象似乎源于红细胞内介质，可能是由于细胞内二氧化碳/碳酸氢盐平衡的改变。pHi的这种下降存在个体差异，表明pH下降的幅度与一些接受醋酸盐血液透析患者中观察到的问题程度相关。
