Hong Jin-ni, Li Wei-wei, Wang Xue-mei
Zhongguo Zhong Yao Za Zhi. 2015 Nov;40(22):4351-4.
Insulin resistance and insulin secretion deficiency are main machanisms in inducing type 2 diabetes mellitus (T2DM), and mitochondria damage plays an important role in them. Research shows that autophagy is a self-protective mechanism of cells, which plays an important role in maintaining the normal structure and function of pancreatic β cells and improving insulin resistance. Previous studies show that traditional Chinese medicine can regulate cell autophagy to influence β cells and insulin resistance, type 2 diabetes mellitus and its complications. Thus this review will talk about the process of the relationship between autophagy and T2DM and the intervention effect of traditional Chinese medicine.
胰岛素抵抗和胰岛素分泌不足是诱发2型糖尿病（T2DM）的主要机制，而线粒体损伤在其中起重要作用。研究表明，自噬是细胞的一种自我保护机制，在维持胰岛β细胞的正常结构和功能以及改善胰岛素抵抗方面发挥重要作用。以往研究表明，中药可通过调节细胞自噬来影响β细胞、胰岛素抵抗、2型糖尿病及其并发症。因此，本文将探讨自噬与T2DM之间的关系过程以及中药的干预作用。
