Zheng Hua, Ge Yanru
School of Pharmacological Science, Jiangsu University, Zhenjiang 212013, China.
Zhongguo Zhong Yao Za Zhi. 2010 Feb;35(4):531-5. doi: 10.4268/cjcmm20100428.
The insulin resistance (IR) and the active ingredients of traditional Chinese medicine and their mechanisms to improve IR in the last 3 years are summarized. Retrieve, classify and arrange the recent documentations of china and abroad. IR can drive the occurrence and progress of type 2 diabetes mellitus (T2DM), and there are several molecular mechanisms for the occurrence of IR. IR has been a research focus of diabetes, the control strategies of T2DM have been changed from the "hypoglycemic therapy" into "improve the IR and IR-related metabolic abnormalities, and make a comprehensive prevention and treatment of cardiovascular risk factors". It is demonstrated by experiments that a variety of active ingredients of traditional Chinese medicine can improve IR through different mechanisms to treat diabetes mellitus.
总结近3年来胰岛素抵抗（IR）及中药活性成分及其改善IR的机制。检索、分类并整理国内外近期文献。IR可推动2型糖尿病（T2DM）的发生与进展，IR的发生存在多种分子机制。IR一直是糖尿病的研究热点，T2DM的控制策略已从“降糖治疗”转变为“改善IR及IR相关代谢异常，并对心血管危险因素进行综合防治”。实验表明，多种中药活性成分可通过不同机制改善IR以治疗糖尿病。
