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[现代干燥技术对玄参质量的影响]

[Effect on quality of Scrophulariae Radix with modern drying technology].

作者信息

Li Hui-wei, Liu Pei, Qian Da-wei, Lu Xue-jun, Guo Sheng, Zhu Zhen-hua, Duan Jin-ao

出版信息

Zhongguo Zhong Yao Za Zhi. 2015 Nov;40(22):4417-23.

Abstract

Modern drying technology was used to explore suitable drying process to provide scientific basis for improving drying processing methods of Scrophulariae Radix. Controlled temperature and humidity drying, vacuum drying apparatus, microwave vacuum drying apparatus, short infrared drying device were used to gain samples for analyzing. The character appearance, concentration of main components and power consumption indicators were chosen for preliminary judging. Six major components, including iridoids and phenylpropanoids were analyzed by UPLC-MS/MS method. The contents of polysaccharides were determined by UV-visible spectrophotometry. The character appearance with controlled temperature and humidity drying and short infrared drying meet the pharmacopoeia standard (Ch. p, edition 2015), while samples with vacuum and microwave vacuum drying apparatus didn't. Compared to fresh sample, concentrations of harpagide, harpagoside, aucubin and catalpol were lower in the dried samples. Angoroside-C showed no significant change before and after drying. Concentration of acteoside increased after drying. Samples with controlled temperature (70 degrees C) and humidity (15% - 10%) drying had high content and short drying time. The better drying process of Scrophulariae Radix was controlled temperature and humidity drying. The method will provide the reference for the drying technology standard of roots medicine.

摘要

采用现代干燥技术探索适宜的干燥工艺,为改进玄参干燥加工方法提供科学依据。利用控温控湿干燥箱、真空干燥仪、微波真空干燥仪、短波红外干燥设备进行样品制备与分析。选取外观性状、主要成分含量及能耗指标进行初步评判。采用超高效液相色谱-串联质谱法(UPLC-MS/MS)分析环烯醚萜类、苯丙素类等6大类成分;采用紫外-可见分光光度法测定多糖含量。控温控湿干燥和短波红外干燥的外观性状符合《中国药典》2015年版标准,真空干燥和微波真空干燥的样品不符合。干燥后样品中哈帕苷、哈巴俄苷、桃叶珊瑚苷和梓醇的含量较鲜品降低;毛蕊花糖苷干燥前后无显著变化;异毛蕊花糖苷干燥后含量升高。70℃、15% - 10%控温控湿干燥的样品有效成分含量高、干燥时间短。玄参较优的干燥工艺为控温控湿干燥,该方法可为根类药材干燥技术规范提供参考。

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