Dar Faisal Saud, Zia Haseeb, Hafeez Bhatti Abu Bakar, Rana Atif, Nazer Rashid, Kazmi Rubab, Khan Etizaz-Ud-Din, Khan Nasir Ayub, Salih Muhammad, Shah Najmul Hassan
Department of HPB and Liver Transplantation, Shifa International Hospital, Islamabad.
Department of Radiology, Shifa International Hospital, Islamabad.
J Coll Physicians Surg Pak. 2016 Apr;26(4):272-6.
To determine the outcome of living-donor liver transplant (LDLT) donors from the first liver transplant program in Pakistan.
Cohort study.
Shifa International Hospital, Islamabad, from April 2012 to August 2014.
A total of 100 live donors who underwent hepatectomy were included. Demographics, etiologies, graft characteristics and operative variables were retrospectively assessed. Outcome was assessed based on morbidity and mortality.
Median donor age was 28 (17 - 45) years and median body mass index (BMI) was 24 kg/m2 (15 - 36). Male to female ratio was 1.5:1. Hepatitis B and C were the most common underlying etiologies and accounted for 79/100 (79%) of LDLT's. Overall, 93/100 (93%) donors donated a right lobe graft. Median estimated graft weight to recipient body weight (GW/BW) ratio was 1.03 (0.78 - 2). Standard arterial anatomy was present in 56% donors. The 90-day morbidity was 13/100 (13%) and overall morbidity was 17/100 (17%). Bile leak was encountered in 3 (3%) patients. There was no donor mortality.
Acceptable short-term donor outcomes were achieved in an LDLT program in Pakistan with careful donor selection and planning.
确定巴基斯坦首个肝移植项目中活体肝移植（LDLT）供者的结局。
队列研究。
2012年4月至2014年8月，伊斯兰堡的希法国际医院。
共纳入100例行肝切除术的活体供者。对人口统计学、病因、移植物特征和手术变量进行回顾性评估。根据发病率和死亡率评估结局。
供者年龄中位数为28岁（17 - 45岁），体重指数（BMI）中位数为24 kg/m²（15 - 36）。男女比例为1.5:1。乙型和丙型肝炎是最常见的潜在病因，占LDLT的79/100（79%）。总体而言，93/100（93%）的供者捐献了右叶移植物。移植物估计重量与受者体重（GW/BW）的中位数比例为1.03（0.78 - 2）。56%的供者具有标准动脉解剖结构。90天发病率为13/100（13%），总体发病率为17/100（17%）。3例（3%）患者出现胆漏。无供者死亡。
通过仔细的供者选择和规划，巴基斯坦的一个LDLT项目取得了可接受的短期供者结局。
