人类和小鼠Ly6/uPAR家族基因的组织、进化及功能
Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
作者信息
Loughner Chelsea L, Bruford Elspeth A, McAndrews Monica S, Delp Emili E, Swamynathan Sudha, Swamynathan Shivalingappa K
机构信息
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA.
HUGO Gene Nomenclature Committee (HGNC), European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
出版信息
Hum Genomics. 2016 Apr 21;10:10. doi: 10.1186/s40246-016-0074-2.
Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide bridge pattern that creates the three-finger Ly6/uPAR (LU) domain. Although the Ly6/uPAR family proteins share a common structure, their expression patterns and functions vary. To date, 35 human and 61 mouse Ly6/uPAR family members have been identified. Based on their subcellular localization, these proteins are further classified as GPI-anchored on the cell membrane, or secreted. The genes encoding Ly6/uPAR family proteins are conserved across different species and are clustered in syntenic regions on human chromosomes 8, 19, 6 and 11, and mouse Chromosomes 15, 7, 17, and 9, respectively. Here, we review the human and mouse Ly6/uPAR family gene and protein structure and genomic organization, expression, functions, and evolution, and introduce new names for novel family members.
淋巴细胞抗原6（Ly6）/尿激酶型纤溶酶原激活物受体（uPAR）超家族蛋白成员是富含半胱氨酸的蛋白，其特征在于独特的二硫键模式，形成三指Ly6/uPAR（LU）结构域。尽管Ly6/uPAR家族蛋白具有共同的结构，但其表达模式和功能各不相同。迄今为止，已鉴定出35个人类和61个小鼠Ly6/uPAR家族成员。根据其亚细胞定位，这些蛋白进一步分为细胞膜上糖基磷脂酰肌醇（GPI）锚定型或分泌型。编码Ly6/uPAR家族蛋白的基因在不同物种间保守，分别聚集在人类染色体8、19、6和11以及小鼠染色体15、7、17和9的同线性区域。在此，我们综述人类和小鼠Ly6/uPAR家族的基因、蛋白结构、基因组组织、表达、功能及进化，并介绍新家族成员的新名称。
Zotero 插件