Rozman C, Montserrat E, Rozman M, Bladé J, Cervantes F
Med Clin (Barc). 1989 Jan 21;92(2):52-5.
In the prognostic evaluations the initial variables, obtained at the time of diagnosis, and the evolutive or time-dependent variables, that appear during the course of the disease, should be clearly differentiated. If this separation is not strictly maintained inaccurate results may be obtained. The errors resulting from the use of an inappropriate methodology are illustrated in the present article on the basis of two series of patients. On the other hand, the advantages and shortcomings of alternative methods, which are valid for prognostic studies with evolutive or time-dependent variables, are discussed. Finally, recommendations are given for the particular instance where the response to therapy in a therapeutic trial is being assessed.
在预后评估中，应明确区分诊断时获得的初始变量以及疾病过程中出现的演变性或时间依赖性变量。如果不严格保持这种区分，可能会得到不准确的结果。本文基于两组患者说明了使用不当方法所导致的误差。另一方面，讨论了适用于具有演变性或时间依赖性变量的预后研究的替代方法的优缺点。最后，针对评估治疗试验中治疗反应的特定情况给出了建议。
