头颈部癌放疗所致吞咽困难的病理生理学
Pathophysiology of Radiation-Induced Dysphagia in Head and Neck Cancer.
作者信息
King Suzanne N, Dunlap Neal E, Tennant Paul A, Pitts Teresa
机构信息
Department of Neurological Surgery, Kentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St MDR 616, Louisville, KY, 40202, USA.
Department of Radiation Oncology, University of Louisville, Louisville, USA.
出版信息
Dysphagia. 2016 Jun;31(3):339-51. doi: 10.1007/s00455-016-9710-1. Epub 2016 Apr 20.
Abstract
Oncologic treatments, such as curative radiotherapy and chemoradiation, for head and neck cancer can cause long-term swallowing impairments (dysphagia) that negatively impact quality of life. Radiation-induced dysphagia comprised a broad spectrum of structural, mechanical, and neurologic deficits. An understanding of the biomolecular effects of radiation on the time course of wound healing and underlying morphological tissue responses that precede radiation damage will improve options available for dysphagia treatment. The goal of this review is to discuss the pathophysiology of radiation-induced injury and elucidate areas that need further exploration.
摘要
头颈部癌症的肿瘤治疗，如根治性放疗和放化疗，可导致长期吞咽障碍（吞咽困难），对生活质量产生负面影响。辐射诱发的吞咽困难包括广泛的结构、机械和神经功能缺陷。了解辐射对伤口愈合时间进程以及辐射损伤前潜在形态学组织反应的生物分子效应，将改善吞咽困难的治疗选择。本综述的目的是讨论辐射诱发损伤的病理生理学，并阐明需要进一步探索的领域。
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