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基于逐个基因方法揭示的奈瑟菌群体与功能基因组学

Population and Functional Genomics of Neisseria Revealed with Gene-by-Gene Approaches.

作者信息

Maiden Martin C J, Harrison Odile B

机构信息

Department of Zoology, University of Oxford, Oxford, United KingdomEmory University

Department of Zoology, University of Oxford, Oxford, United KingdomEmory University.

出版信息

J Clin Microbiol. 2016 Aug;54(8):1949-55. doi: 10.1128/JCM.00301-16. Epub 2016 Apr 20.

DOI:10.1128/JCM.00301-16
PMID:27098959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4963508/
Abstract

Rapid low-cost whole-genome sequencing (WGS) is revolutionizing microbiology; however, complementary advances in accessible, reproducible, and rapid analysis techniques are required to realize the potential of these data. Here, investigations of the genus Neisseria illustrated the gene-by-gene conceptual approach to the organization and analysis of WGS data. Using the gene and its link to phenotype as a starting point, the BIGSdb database, which powers the PubMLST databases, enables the assembly of large open-access collections of annotated genomes that provide insight into the evolution of the Neisseria, the epidemiology of meningococcal and gonococcal disease, and mechanisms of Neisseria pathogenicity.

摘要

快速低成本全基因组测序（WGS）正在彻底改变微生物学；然而，需要在可访问、可重复和快速分析技术方面取得互补性进展，以实现这些数据的潜力。在这里，对奈瑟菌属的研究阐明了逐个基因的概念方法，用于WGS数据的组织和分析。以基因及其与表型的联系为起点，为PubMLST数据库提供支持的BIGSdb数据库能够组装大量开放获取的注释基因组集合，这些集合有助于深入了解奈瑟菌的进化、脑膜炎球菌和淋球菌疾病的流行病学以及奈瑟菌致病性机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/563e152967ff/zjm9990950240004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/e0d77cff27bb/zjm9990950240001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/4e202e8d3064/zjm9990950240002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/32c9fe3cad99/zjm9990950240003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/461d49f93e93/zjm9990950240005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/563e152967ff/zjm9990950240004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/e0d77cff27bb/zjm9990950240001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/4e202e8d3064/zjm9990950240002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/32c9fe3cad99/zjm9990950240003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/461d49f93e93/zjm9990950240005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42aa/4963508/563e152967ff/zjm9990950240004.jpg

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