Domínguez-Castellano A, Peña J M, Barbado F J, González J J, Madero R, León L, Arnalich F, Vázquez J J
Med Clin (Barc). 1989 Jan 28;92(3):81-5.
We have evaluated 100 biopsies of temporal artery carried out in the Hospital La Paz from 1972 to 1986. On the basis of the histological result and the final diagnosis we divided the patients in five groups: I, temporal arteritis/polymyalgia rheumatica with positive biopsy, 11 cases; II, temporal arteritis without polymyalgia symptoms and with positive biopsy, 16 cases; III, temporal arteritis with negative biopsy, 7 cases; IV, polymyalgia with negative biopsy, 14 cases; and V, other diagnoses, 43 cases. The number of diagnoses of temporal arteritis/polymyalgia rheumatica has increased throughout the recent years, although the positive biopsies/overall biopsies ratio has remained constant. Certain symptoms such as claudication, headache, amaurosis and Raynaud's phenomenon have a high predictive value of a positive result, but their sensitivity is low. In the 25 patients with polymyalgia, biopsy was positive in 11, out of which 4 did not have features of temporal arteritis. Biopsy was positive in 4 out of the 9 patients in whom it was repeated in the contralateral side. The diagnostic yield was higher in those cases in whom it was indicated for classical temporal arteritis symptoms, but we emphasize that there was a 19% positive rate in patients who presented with fever of unknown origin, while it was only 5.5% in those in whom a constitutional syndrome was being evaluated. We conclude that the use of temporal biopsy should be more widespread, as its cost is low and it has no side effects; therefore, it can achieve a great benefit for the patient with a shorter and less expensive hospital stay.
我们评估了1972年至1986年在拉巴斯医院进行的100例颞动脉活检。根据组织学结果和最终诊断,我们将患者分为五组:I组,活检阳性的颞动脉炎/风湿性多肌痛,11例;II组,无风湿性多肌痛症状且活检阳性的颞动脉炎,16例;III组,活检阴性的颞动脉炎,7例;IV组,活检阴性的风湿性多肌痛,14例;V组,其他诊断,43例。近年来,颞动脉炎/风湿性多肌痛的诊断数量有所增加,尽管活检阳性率与总活检率之比保持不变。某些症状,如跛行、头痛、黑矇和雷诺现象,对阳性结果具有较高的预测价值,但它们的敏感性较低。在25例风湿性多肌痛患者中,11例活检呈阳性,其中4例没有颞动脉炎的特征。在9例对侧重复活检的患者中,4例呈阳性。对于具有典型颞动脉炎症状的患者,活检的诊断率较高,但我们强调,不明原因发热患者的阳性率为19%,而在评估全身性综合征的患者中仅为5.5%。我们得出结论,颞动脉活检的应用应更广泛,因为其成本低且无副作用;因此,它可以在较短且费用较低的住院时间内为患者带来很大益处。