Serafini Mairim Russo, Guimaraes Adriana Gibara, Quintans-Junior Lucindo Jose, Nunes Paula Santos, Matos Isabella Goncalves, Saravanan Shanmugam, de Souza Araujo Adriano Antunes
Department of Pharmacy, University of Sergipe, Lagarto, Brazil.
Recent Pat Biotechnol. 2014;8(3):231-9. doi: 10.2174/187220830803150605164205.
For healing wounds, burns and ulcers has a great impact on economy. New medications, technologies and other interventions are being used for skin injuries and to eliminate infections. Despite several technological and strategic advances in this field, wound care has returned to the roots of medicine and some of the remedies used millennia ago have been studied at present. This review gives an awareness of commercially available drugs to healing of wounds from natural origin. The research was conducted based on the requests for patents deposited in the Espacenet (European Patent Office) and in the WIPO (World Intellectual Property Organization). The research focused on exploring the uses of medicinal plants/natural products as a therapeutic approach to wounds and burns healing. Further, this study discusses the recent trends in the usage of natural products in topical formulations and the patents on it were reviewed, in addition to, future investigations and application of natural products in healing of wounds. Natural products have great therapeutic potential and should be used in the development of new products for the treatment of skin injuries.
对于伤口、烧伤和溃疡的愈合对经济有重大影响。新的药物、技术和其他干预措施正被用于皮肤损伤及消除感染。尽管该领域在技术和策略上取得了多项进展,但伤口护理已回归医学根源,目前对数千年前使用的一些疗法进行了研究。本综述介绍了可用于伤口愈合的天然来源的市售药物。该研究是根据在欧洲专利局(Espacenet)和世界知识产权组织(WIPO)提交的专利申请进行的。该研究重点探索药用植物/天然产物作为伤口和烧伤愈合治疗方法的用途。此外,本研究讨论了天然产物在局部制剂中的最新使用趋势,并对其相关专利进行了综述,还探讨了天然产物在伤口愈合方面的未来研究及应用。天然产物具有巨大的治疗潜力,应在开发治疗皮肤损伤的新产品中加以利用。