Bergström T
Lakartidningen. 1989 Apr 5;86(14):1279-80.
Mollaret's meningitis is characterised by recurrent, brief episodes of serous meningitis with symptom-free intervals. Although viral etiology has been suspected, no pathogenic agent has hitherto been found. Using the immunoblot technique, we found IgG antibodies of intrathecal origin against the HSV-2-specific protein, gG2, in a patient with Mollaret's meningitis. Since being put on prophylactic acyclovir treatment twelve months ago, the patient has had no further episodes of meningitis. Because of the similarities between Mollaret's meningitis, recurrent HSV-2 meningitis, and the findings in the case reported here, HSV-2 is suggested as a possible cause of Mollaret's meningitis in general.
莫拉雷脑膜炎的特征是浆液性脑膜炎反复发作且发作短暂，发作间期无症状。尽管一直怀疑有病毒病因，但迄今尚未发现病原体。我们运用免疫印迹技术，在一名莫拉雷脑膜炎患者体内发现了鞘内产生的针对单纯疱疹病毒2型特异性蛋白gG2的IgG抗体。自从12个月前开始接受预防性阿昔洛韦治疗以来，该患者未再出现脑膜炎发作。鉴于莫拉雷脑膜炎、复发性单纯疱疹病毒2型脑膜炎以及此处报告病例的发现之间存在相似性，总体上提示单纯疱疹病毒2型可能是莫拉雷脑膜炎的病因。
