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[疱疹性复发性莫拉雷脑膜炎]

[Recurrent Mollaret's meningitis of herpetic origin].

作者信息

Gignoux L, Ryvlin P, Najioullah F, Mauguière F

机构信息

Service du Pr Mauguière, Unité 301, Hôpital Neurologíque, Lyon.

出版信息

Presse Med. 1998 Oct 3;27(29):1470-2.

PMID:9798461
Abstract

BACKGROUND

Benign recurrent meningitis, or Mollaret's meningitis, is an uncommon disease whose viral origin was long unidentified. Since 1991, about twenty cases have been reported in patients with herpes infection.

CASE REPORT

A female patient had experienced repeated episodes of spontaneous meningitis since 1983. The episodes resolved spontaneously and no etiology had been identified. A spinal tap was performed when the patient was again hospitalized a new episode of meningitis and PCR amplification of the herpes simplex virus type 2 (HSV 2) was positive. The patient was given long term acyclovir per os. A new spinal tap after resolution of the meningitis episode was PCR HSV2 negative.

DISCUSSION

HSV2 infection is one of the known causes of Mollaret's meningitis. Long-term antiviral therapy appears to prevent recurrence as was observed in our patient.

摘要

背景

良性复发性脑膜炎,即莫拉雷脑膜炎,是一种罕见疾病,其病毒起源长期未明。自1991年以来,已有约20例疱疹感染患者的病例报告。

病例报告

一名女性患者自1983年起反复出现自发性脑膜炎发作。发作可自行缓解,病因未明。当患者因新的脑膜炎发作再次住院时进行了腰椎穿刺,单纯疱疹病毒2型(HSV 2)的聚合酶链反应(PCR)扩增呈阳性。患者接受了长期口服阿昔洛韦治疗。脑膜炎发作缓解后再次进行腰椎穿刺,PCR检测HSV2呈阴性。

讨论

HSV2感染是莫拉雷脑膜炎的已知病因之一。正如我们在患者中观察到的那样,长期抗病毒治疗似乎可预防复发。

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