Lusis Aldons J, Seldin Marcus M, Allayee Hooman, Bennett Brian J, Civelek Mete, Davis Richard C, Eskin Eleazar, Farber Charles R, Hui Simon, Mehrabian Margarete, Norheim Frode, Pan Calvin, Parks Brian, Rau Christoph D, Smith Desmond J, Vallim Thomas, Wang Yibin, Wang Jessica
Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA Microbiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA
Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA.
J Lipid Res. 2016 Jun;57(6):925-42. doi: 10.1194/jlr.R066944. Epub 2016 Apr 19.
The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as human genome-wide association studies, it has some important advantages. First, environmental factors can be controlled. Second, relevant tissues are accessible for global molecular phenotyping. Finally, because inbred strains are renewable, results from separate studies can be integrated. Thus far, the HMDP has been studied for traits relevant to obesity, diabetes, atherosclerosis, osteoporosis, heart failure, immune regulation, fatty liver disease, and host-gut microbiota interactions. High-throughput technologies have been used to examine the genomes, epigenomes, transcriptomes, proteomes, metabolomes, and microbiomes of the mice under various environmental conditions. All of the published data are available and can be readily used to formulate hypotheses about genes, pathways and interactions.
杂交小鼠多样性面板（HMDP）是一组约100个特征明确的近交系小鼠，可用于分析复杂性状背后的遗传和环境因素。虽然在定位影响性状的基因座方面，它远不如人类全基因组关联研究强大，但它有一些重要优势。首先，环境因素可以得到控制。其次，可获取相关组织用于整体分子表型分析。最后，由于近交系是可再生的，不同研究的结果可以整合。到目前为止，已经针对与肥胖、糖尿病、动脉粥样硬化、骨质疏松症、心力衰竭、免疫调节、脂肪肝疾病以及宿主-肠道微生物群相互作用相关的性状对HMDP进行了研究。高通量技术已被用于在各种环境条件下检测小鼠的基因组、表观基因组、转录组、蛋白质组、代谢组和微生物组。所有已发表的数据均可获取，并且可随时用于构建关于基因、信号通路和相互作用的假设。
