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过氧化氢对酿酒酵母的 hormetic 效应：TOR 和谷胱甘肽还原酶的作用

Hormetic Effect of H2O2 in Saccharomyces cerevisiae: Involvement of TOR and Glutathione Reductase.

作者信息

Semchyshyn Halyna M, Valishkevych Bohdana V

机构信息

Department of Biochemistry and Biotechnology, Vassyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.

出版信息

Dose Response. 2016 Mar 30;14(2):1559325816636130. doi: 10.1177/1559325816636130. eCollection 2016 Apr-Jun.

DOI:10.1177/1559325816636130
PMID:27099601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4822199/
Abstract

In this study, we investigated the relationship between target of rapamycin (TOR) and H2O2-induced hormetic response in the budding yeast Saccharomyces cerevisiae grown on glucose or fructose. In general, our data suggest that: (1) hydrogen peroxide (H2O2) induces hormesis in a TOR-dependent manner; (2) the H2O2-induced hormetic dose-response in yeast depends on the type of carbohydrate in growth medium; (3) the concentration-dependent effect of H2O2 on yeast colony growth positively correlates with the activity of glutathione reductase that suggests the enzyme involvement in the H2O2-induced hormetic response; and (4) both TOR1 and TOR2 are involved in the reciprocal regulation of the activity of glucose-6-phosphate dehydrogenase and glyoxalase 1.

摘要

在本研究中，我们调查了雷帕霉素靶蛋白（TOR）与在葡萄糖或果糖上生长的出芽酵母酿酒酵母中过氧化氢（H2O2）诱导的兴奋效应之间的关系。总体而言，我们的数据表明：（1）过氧化氢（H2O2）以TOR依赖的方式诱导兴奋效应；（2）酵母中H2O2诱导的兴奋剂量反应取决于生长培养基中碳水化合物的类型；（3）H2O2对酵母菌落生长的浓度依赖性效应与谷胱甘肽还原酶的活性呈正相关，这表明该酶参与了H2O2诱导的兴奋效应；（4）TOR1和TOR2都参与了6-磷酸葡萄糖脱氢酶和乙二醛酶1活性的相互调节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/d2d8db596101/10.1177_1559325816636130-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/e977ffa85914/10.1177_1559325816636130-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/594da14d62a6/10.1177_1559325816636130-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/6c0419d48156/10.1177_1559325816636130-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/308bc7bedd70/10.1177_1559325816636130-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/37322ea73c98/10.1177_1559325816636130-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/2436fc46486f/10.1177_1559325816636130-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/d2d8db596101/10.1177_1559325816636130-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/e977ffa85914/10.1177_1559325816636130-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/594da14d62a6/10.1177_1559325816636130-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/6c0419d48156/10.1177_1559325816636130-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/308bc7bedd70/10.1177_1559325816636130-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/37322ea73c98/10.1177_1559325816636130-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/2436fc46486f/10.1177_1559325816636130-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ee2/4822199/d2d8db596101/10.1177_1559325816636130-fig7.jpg

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