Lauretani Fulvio, Ticinesi Andrea, Meschi Tiziana, Teresi Giulio, Ceda Gian Paolo, Maggio Marcello
Geriatric Clinic and Laboratory of Movement Analysis, Geriatric and Rehabilitation Department, University Hospital of Parma, Via Gramsci 14, I-431126 Parma, Italy,
Internal Medicine and Critical Subacute Care Unit, Parma University Hospital, Via Gramsci 14, I-431126 Parma, Italy and Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, I-431126 Parma, Italy.
Front Biosci (Elite Ed). 2016 Jun 1;8(3):378-89. doi: 10.2741/E774.
The continuous increase in elderly and oldest-old population, and subsequent rise in prevalence of chronic neurological diseases like Alzheimer's disease (AD) and Parkinson's disease (PD), are a major challenge for healthcare systems. These two conditions are the most prevalent neurodegenerative diseases in older persons and physicians should engage treatment for these patients. In this field, Randomized Clinical Trials (RCTs) specifically focused on elderly populations are still lacking. The aim of this study was to identify RCTs conducted among AD and PD and to examine the difference between mean age of enrollment and incidence of these two neurodegenerative diseases. We found that the scenario is different between PD and AD. In particular, the enrollment for PD trials seems to include younger persons than AD, although the incidence of both diseases is similar and highest after 80 years old. The consequence of these results could influence conclusive guidelines of treatment in older parkinsonian patients.
老年和高龄人口的持续增长，以及随之而来的阿尔茨海默病（AD）和帕金森病（PD）等慢性神经疾病患病率的上升，是医疗保健系统面临的一项重大挑战。这两种疾病是老年人中最常见的神经退行性疾病，医生应为这些患者进行治疗。在该领域，仍缺乏专门针对老年人群体的随机临床试验（RCT）。本研究的目的是确定在AD和PD患者中开展的RCT，并检验入组平均年龄与这两种神经退行性疾病发病率之间的差异。我们发现PD和AD的情况有所不同。特别是，PD试验的入组人群似乎比AD试验的入组人群更年轻，尽管两种疾病的发病率相似，且在80岁之后发病率最高。这些结果可能会影响老年帕金森病患者的确定性治疗指南。
