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[糖尿病、慢性肾衰竭和肝硬化中的自主神经病变]

[Autonomic neuropathy in diabetes mellitus, chronic renal failure and liver cirrhosis].

作者信息

Bielefeldt K, Reis H E

出版信息

Med Klin (Munich). 1989 Feb 15;84(2):72-6.

PMID:2710053
Abstract

Chronic diseases (diabetes mellitus, end stage renal failure on hemodialysis, post-hepatitic liver cirrhosis) caused autonomic neuropathy in 34 of 65 cases. The frequency of autonomic neuropathy was 14 of 30 diabetics (typ I and typ II), twelve of 19 patients on dialysis, and eight of 16 non-alcoholic liver cirrhotics. We did not find a correlation between the tests of the cardiovascular and of the gastrointestinal system. The distribution of the neuropathic changes was undependent of the underlying disorder. Using appropriate tests, alterations of the autonomic functions can be discovered frequently even in asymptomatic patients. At least two pathological test results are necessary to reach a significant difference between patients and healthy controls. This indicates that the diagnosis of autonomic neuropathy should rely on two or more pathological test results. The evidence of autonomic neuropathy identifies a population of high risk patients.

摘要

慢性病(糖尿病、接受血液透析的终末期肾衰竭、肝炎后肝硬化)在65例患者中有34例引发了自主神经病变。自主神经病变的发生率在30例糖尿病患者(Ⅰ型和Ⅱ型)中为14例,19例透析患者中为12例,16例非酒精性肝硬化患者中为8例。我们未发现心血管系统和胃肠道系统检查结果之间存在相关性。神经病变改变的分布与潜在疾病无关。通过适当的检查,即使在无症状患者中也能频繁发现自主神经功能改变。患者与健康对照之间至少需要两项病理检查结果存在显著差异。这表明自主神经病变的诊断应基于两项或更多项病理检查结果。自主神经病变的证据可识别出高危患者群体。

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