拓扑异构酶IIb和DNA双链断裂在转录中的关键作用。
A critical role for topoisomerase IIb and DNA double strand breaks in transcription.
作者信息
Calderwood Stuart K
机构信息
a Department of Radiation Oncology , Harvard Medical School at Beth Israel Deaconess Medical Center , Boston , MA , USA.
出版信息
Transcription. 2016 May 26;7(3):75-83. doi: 10.1080/21541264.2016.1181142. Epub 2016 Apr 21.
Abstract
Recent studies have indicated a novel role for topoisomerase IIb in transcription. Transcription of heat shock genes, serum-induced immediate early genes and nuclear receptor-activated genes, each required DNA double strands generated by topoisomerase IIb. Such strand breaks seemed both necessary and sufficient for transcriptional activation. In addition, such transcription was associated with initiation of the DNA damage response pathways, including the activation of the enzymes: ataxia-telangiectasia mutated (ATM), DNA-dependent protein kinase and poly (ADP ribose) polymerase 1. DNA damage response signaling was involved both in transcription and in repair of DNA breaks generated by topoisomerase IIb.
摘要
最近的研究表明拓扑异构酶IIb在转录过程中具有新的作用。热休克基因、血清诱导的立即早期基因和核受体激活基因的转录，均需要拓扑异构酶IIb产生的DNA双链。这种链断裂似乎对于转录激活既是必要的也是充分的。此外，这种转录与DNA损伤反应途径的启动相关，包括以下酶的激活：共济失调毛细血管扩张症突变基因（ATM）、DNA依赖性蛋白激酶和聚（ADP核糖）聚合酶1。DNA损伤反应信号传导参与了转录以及拓扑异构酶IIb产生的DNA断裂的修复。
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