Stewart C R, Nandedkar S D, Massey J M, Gilchrist J M, Barkhaus P E, Sanders D B
Division of Neurology, Duke University Medical Center, Durham, NC 27710.
Muscle Nerve. 1989 Feb;12(2):141-8. doi: 10.1002/mus.880120209.
This study was performed to evaluate an automatic method of motor unit action potential (MUAP) analysis developed in our laboratory. MUAPs were recorded from the biceps brachii muscle of 68 normal subjects and 122 patients with nerve or muscle disease. The values of mean MUAP durations from normal subjects obtained by automatic analysis were similar to those reported in the literature. However, the normal range of MUAP amplitude and the incidence of polyphasic MUAPs were much higher. Normal ranges of mean MUAP area, area/amplitude ratio, and the number of turns were also defined. Automatic analysis demonstrated an abnormality of at least one MUAP feature in 70% of patients. There was concordance between automated analysis and visual assessment of MUAPs in 76% of patients with neuropathy but in only 50% of patients with myopathy. The relationships between different MUAP features seen in neuropathy and myopathy are explained in physiologic terms.
本研究旨在评估我们实验室开发的一种运动单位动作电位（MUAP）自动分析方法。从68名正常受试者和122名患有神经或肌肉疾病的患者的肱二头肌记录MUAP。通过自动分析获得的正常受试者的平均MUAP持续时间值与文献报道的值相似。然而，MUAP波幅的正常范围和多相MUAP的发生率要高得多。还定义了平均MUAP面积、面积/波幅比和转折数的正常范围。自动分析显示70%的患者至少有一项MUAP特征异常。在76%的神经病变患者中，自动分析与MUAP的视觉评估结果一致，但在仅有50%的肌病患者中一致。从生理学角度解释了神经病变和肌病中不同MUAP特征之间的关系。
