Magenta Alessandra, Dellambra Elena, Ciarapica Roberta, Capogrossi Maurizio C
Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, Laboratorio di Patologia Vascolare, Via dei Monti di Creta 104, Rome 00167, Italy.
Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, Laboratorio di Patologia Vascolare, Via dei Monti di Creta 104, Rome 00167, Italy.
Cell Calcium. 2016 Sep;60(3):207-17. doi: 10.1016/j.ceca.2016.04.002. Epub 2016 Apr 8.
Reactive oxygen species increase cytosolic [Ca(2+)], (Cai), and also modulate the expression of some microRNAs (miRNAs), however the link among oxidative stress, miRNAs and Cai is poorly characterized. In this review we have focused on three groups of miRNAs: (a) miRNAs that are modulated both by ROS and Cai: miR-181a and miR-205; (b) miRNAs that are modulated by ROS and have an effect on Cai: miR-1, miR-21, miR-24, miR-25, miR-185 and miR-214; (c) miRNAs that modulate both ROS and Cai: miR-133; miR-145, miR-495, and we have analyzed their effects on cell signaling and cell function. Finally, in the last section we have examined the role of these miRNAs in the skin, under conditions associated with enhanced oxidative stress, i.e. skin aging, the response to ultraviolet light and two important skin diseases, psoriasis and atopic dermatitis. It is apparent that although some experimental evidence is already available on (a) the role of Cai in miRNAs expression and (b) on the ability of some miRNAs to modulate Cai-dependent intracellular signaling, these research lines are still largely unexplored and represent important areas of future studies.
活性氧会增加细胞质中钙离子浓度（[Ca(2+)]，即Cai），还能调节一些微小RNA（miRNA）的表达，然而氧化应激、miRNA与Cai之间的联系却鲜有研究。在这篇综述中，我们重点关注了三组miRNA：（a）受活性氧和Cai共同调节的miRNA：miR-181a和miR-205；（b）受活性氧调节且对Cai有影响的miRNA：miR-1、miR-21、miR-24、miR-25、miR-185和miR-214；（c）调节活性氧和Cai的miRNA：miR-133、miR-145、miR-495，我们分析了它们对细胞信号传导和细胞功能的影响。最后，在最后一部分中，我们研究了在氧化应激增强的情况下，即皮肤老化、对紫外线的反应以及两种重要的皮肤疾病——银屑病和特应性皮炎中，这些miRNA在皮肤中的作用。很明显，尽管已经有一些关于（a）Cai在miRNA表达中的作用以及（b）一些miRNA调节Cai依赖性细胞内信号传导能力的实验证据，但这些研究方向仍在很大程度上未被探索，是未来研究的重要领域。
