Hu Jingyi, Bian Qiong, Ma Xiaolu, Xu Yihua, Gao Jianqing
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
College of Pharmacy, Inner Mongolia Medical University, Hohhot 010000, China.
Asian J Pharm Sci. 2022 Nov;17(6):798-816. doi: 10.1016/j.ajps.2022.10.005. Epub 2022 Nov 13.
In the onset and progression of psoriasis, redox imbalance is a vital factor. It's widely accepted that too much reactive oxygen species (ROS) always make psoriasis worse. Recent research, however, has shown that the accumulation of ROS is not entirely detrimental, as it helps reduce psoriasis lesions by inhibiting epidermal proliferation and keratinocyte death. As a result, ROS appears to have two opposing effects on the treatment of psoriasis. In this review, the current ROS-related therapies for psoriasis, including basic and clinical research, are presented. Additionally, the design and therapeutic benefits of various drug delivery systems and therapeutic approaches are examined, and a potential balance between anti-oxidative stress and ROS accumulation is also trying to be investigated.
在银屑病的发病和进展过程中，氧化还原失衡是一个关键因素。人们普遍认为，过多的活性氧（ROS）总是会使银屑病病情加重。然而，最近的研究表明，ROS的积累并不完全有害，因为它通过抑制表皮增殖和角质形成细胞死亡来帮助减轻银屑病皮损。因此，ROS似乎对银屑病的治疗有两种相反的作用。在这篇综述中，介绍了目前用于治疗银屑病的与ROS相关的疗法，包括基础研究和临床研究。此外，还研究了各种药物递送系统和治疗方法的设计及其治疗益处，并且试图探究抗氧化应激和ROS积累之间的潜在平衡。
Zotero 插件
