Carvalho Mariana A, Bernardes Lisandra S, Hettfleisch Karen, Pastro Luciana D M, Vieira Sandra E, Saldiva Silvia R D M, Saldiva Paulo H N, Francisco Rossana P V
Procriar Study Group, São Paulo University, São Paulo, Brazil; Department of Obstetrics and Gynecology, São Paulo University School of Medicine, Brazil.
Procriar Study Group, São Paulo University, São Paulo, Brazil; Department of Obstetrics and Gynecology, São Paulo University School of Medicine, Brazil.
Reprod Toxicol. 2016 Jul;62:9-17. doi: 10.1016/j.reprotox.2016.04.013. Epub 2016 Apr 19.
We determined the influence of maternal air pollution exposure during each trimester of pregnancy on fetal and birth weight and fetoplacental hemodynamics. In total, 366 women with singleton pregnancies were prospectively followed in the city of São Paulo, Brazil. Nitrogen dioxide (NO2) and ozone (O3) were measured during each trimester using passive personal samplers. We evaluated fetal weight and Doppler velocimetry data from the umbilical, middle cerebral, and uterine arteries in the 3rd trimester, and birth weight. Multivariate analysis was performed, controlling for known determinants of fetal weight. Exposure to higher levels of O3 during the 2nd trimester was associated with higher umbilical artery pulsatility indices (PIs) [p=0.013; beta=0.017: standard error (SE)=0.007]. Exposure to higher levels of O3 during the 3rd trimester was associated with lower umbilical artery PIs (p=0.011; beta=-0.021; SE=0.008). Our results suggest that in the environment of São Paulo, O3 may affects placental vascular resistance.
我们确定了孕期各阶段母亲暴露于空气污染对胎儿体重、出生体重和胎儿-胎盘血流动力学的影响。在巴西圣保罗市，我们对366名单胎妊娠女性进行了前瞻性随访。在孕期各阶段使用被动式个人采样器测量二氧化氮（NO₂）和臭氧（O₃）。我们评估了孕晚期胎儿体重以及脐动脉、大脑中动脉和子宫动脉的多普勒测速数据，还有出生体重。进行了多变量分析，对已知的胎儿体重决定因素进行了控制。孕中期暴露于较高水平的O₃与较高的脐动脉搏动指数（PI）相关[p = 0.013；β = 0.017：标准误差（SE）= 0.007]。孕晚期暴露于较高水平的O₃与较低的脐动脉PI相关（p = 0.011；β = -0.021；SE = 0.008）。我们的结果表明，在圣保罗的环境中，O₃可能会影响胎盘血管阻力。
