Kim So-Youn
Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Clin Exp Reprod Med. 2016 Mar;43(1):1-8. doi: 10.5653/cerm.2016.43.1.1. Epub 2016 Mar 31.
Granulosa cell tumors (GCTs) are rare sex cord-stromal tumors that have been studied for decades. However, their infrequency has delayed efforts to research their etiology. Recently, mutations in human GCTs have been discovered, which has led to further research aimed at determining the molecular mechanisms underlying the disease. Mouse models have been important tools for studying GCTs, and have provided means to develop and improve diagnostics and therapeutics. Thus far, several genetically modified mouse models, along with one spontaneous mouse model, have been reported. This review summarizes the phenotypes of these mouse models and their applicability in elucidating the mechanisms of granulosa cell tumor development.
颗粒细胞瘤（GCTs）是罕见的性索间质肿瘤，几十年来一直受到研究。然而，其罕见性延缓了对其病因的研究工作。最近，在人类GCTs中发现了突变，这引发了进一步的研究，旨在确定该疾病背后的分子机制。小鼠模型一直是研究GCTs的重要工具，并为开发和改进诊断及治疗方法提供了途径。迄今为止，已经报道了几种基因工程小鼠模型以及一种自发小鼠模型。本综述总结了这些小鼠模型的表型及其在阐明颗粒细胞瘤发生机制方面的适用性。
