Liu Chuchu, Wei Jinlong, Wang Xuanzhong, Zhao Qin, Lv Jincai, Tan Zining, Xin Ying, Jiang Xin
Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China.
Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, China.
Front Cell Dev Biol. 2024 Oct 9;12:1480571. doi: 10.3389/fcell.2024.1480571. eCollection 2024.
According to official statistics, cancer remains the main reason of death and over 50% of patients with cancer receive radiotherapy. However, adverse consequences after radiation exposure like radiation-induced skin reactions (RISR) have negative or even fatal impact on patients' quality of life (QoL). In this review we summarize the mechanisms and managements of RISRs, a process that involve a variety of extracellular and intracellular signals, among which oxidative stress (OS) are now commonly believed to be the initial part of the occurrence of all types of RISRs. As for the management of RISRs, traditional treatments have been widely used but without satisfying outcomes while some promising therapeutic strategies related to OS still need further researches. In the context we discuss how OS leads to the happening of RISRs of different types, hoping it can shed some light on the exploration of new countermeasures.
根据官方统计，癌症仍然是主要死因，超过50%的癌症患者接受放射治疗。然而，辐射暴露后的不良后果，如放射性皮肤反应（RISR），会对患者的生活质量（QoL）产生负面甚至致命影响。在本综述中，我们总结了RISR的机制和管理方法，这一过程涉及多种细胞外和细胞内信号，其中氧化应激（OS）现在普遍被认为是所有类型RISR发生的初始部分。至于RISR的管理，传统治疗方法已被广泛使用，但效果并不理想，而一些与OS相关的有前景的治疗策略仍需进一步研究。在此背景下，我们讨论了OS如何导致不同类型的RISR发生，希望能为探索新的应对措施提供一些启示。
