Morales-Roselló José, Khalil Asma, Alba-Redondo Amparo, Martinez-Triguero Luisa, Akhoundova Farida, Perales-Marín Alfredo, Thilaganathan Basky
Servicio de Obstetricia, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Fetal Diagn Ther. 2017;41(1):15-22. doi: 10.1159/000445114. Epub 2016 Apr 23.
To evaluate the umbilical cord venous S100β levels in late-pregnancy fetuses with abnormal growth and cerebral redistribution.
The pulsatility index of the umbilical and middle cerebral arteries and the cerebroplacental ratio (CPR) were measured in 132 fetuses at ≥34 weeks, and the CPR was converted into multiples of the median (MoM). A blood sample from the umbilical vein was collected at birth, and the umbilical venous S100β levels were evaluated in small and non-small for gestational age (SGA) fetuses, with and without abnormal Doppler indices. The levels of S100β were correlated with birth weight (BW) centile, CPR MoM and cord venous pH.
While CPR MoM correlated with BW centile, S100β showed no correlation with any of the studied fetal parameters. In addition, no differences were observed in S100β level according to BW centile or Doppler parameters, neither was there any difference between SGA with low CPR MoM and non-SGA with normal CPR MoM.
Late-pregnancy fetuses with abnormal growth or cerebral redistribution have normal cord blood levels of S100β at birth. In these fetuses, the potential consequences of chronic hypoxemia on the fetal brain might not be detectable using tissue necrosis markers.
评估生长异常及脑血流重新分布的晚期妊娠胎儿的脐静脉S100β水平。
对132例孕周≥34周的胎儿测量脐动脉和大脑中动脉的搏动指数以及脑胎盘比率（CPR），并将CPR转换为中位数倍数（MoM）。出生时采集脐静脉血样本，评估小于胎龄儿（SGA）和适于胎龄儿（AGA）胎儿、有无异常多普勒指数情况下的脐静脉S100β水平。S100β水平与出生体重（BW）百分位数、CPR MoM及脐静脉pH值进行相关性分析。
虽然CPR MoM与BW百分位数相关，但S100β与所研究的任何胎儿参数均无相关性。此外，根据BW百分位数或多普勒参数未观察到S100β水平存在差异，CPR MoM低的SGA胎儿与CPR MoM正常的AGA胎儿之间也无差异。
生长异常或脑血流重新分布的晚期妊娠胎儿出生时脐血S100β水平正常。在这些胎儿中，使用组织坏死标志物可能无法检测到慢性低氧血症对胎儿脑的潜在影响。
