Klembovskiĭ A I
Pediatriia. 1989(1):53-60.
Altogether 412 children aged 1 to 15 years with chronic nephropathies of various etiology were examined. Methods of clinical morphology were applied. It is marked that in 42 percent of cases the development of glomerular and interstitial nephropathies was caused by foregoing disorders in the formation of the renal structure, chiefly at the tissue and cell levels. It is assumed that the majority of those disorders are multifactorial in nature. Alterations in cell membranes and in supramembraneous biopolymeric layers were also seen, being associated with the definite clinical symptomatology. It is stressed that of paramount importance is the design of the methods of stimulating therapy for correction of renal developmental abnormalities with a decrease of the risk of immunopathologic responses, chronic inflammation and nephrosclerosis.
共对412名年龄在1至15岁之间、患有各种病因慢性肾病的儿童进行了检查。采用了临床形态学方法。结果表明，在42%的病例中，肾小球和间质性肾病的发生是由先前肾脏结构形成过程中的紊乱所致，主要发生在组织和细胞水平。据推测，这些紊乱大多具有多因素性质。还观察到细胞膜和膜上生物聚合物层的改变，这些改变与特定的临床症状相关。强调了设计刺激疗法的方法以纠正肾脏发育异常并降低免疫病理反应、慢性炎症和肾硬化风险的至关重要性。
