[Dysplastic bases of the development of kidney diseases in childhood].

Altogether 412 children aged 1 to 15 years with chronic nephropathies of various etiology were examined. Methods of clinical morphology were applied. It is marked that in 42 percent of cases the development of glomerular and interstitial nephropathies was caused by foregoing disorders in the formation of the renal structure, chiefly at the tissue and cell levels. It is assumed that the majority of those disorders are multifactorial in nature. Alterations in cell membranes and in supramembraneous biopolymeric layers were also seen, being associated with the definite clinical symptomatology. It is stressed that of paramount importance is the design of the methods of stimulating therapy for correction of renal developmental abnormalities with a decrease of the risk of immunopathologic responses, chronic inflammation and nephrosclerosis.