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一种用于多通道心电图中QRS波群检测的新方法:在胎儿健康自我监测中的应用。

A new method for QRS complex detection in multichannel ECG: Application to self-monitoring of fetal health.

作者信息

Varanini Maurizio, Tartarisco Gennaro, Balocchi Rita, Macerata Alberto, Pioggia Giovanni, Billeci Lucia

机构信息

Institute of Clinical Physiology, National Research Council, Pisa, Italy.

Institute of Applied Sciences and Intelligent Systems, National Research Council, Messina, Italy.

出版信息

Comput Biol Med. 2017 Jun 1;85:125-134. doi: 10.1016/j.compbiomed.2016.04.008. Epub 2016 Apr 13.

Abstract

This paper proposes a new approach for QRS complex detection in multichannel ECG and presents its application to fetal QRS (fQRS) detection in signals acquired from maternal abdominal leads. The method exploits the characteristics of pseudo-periodicity and time shape of QRS, it consists of devising a quality index (QI) which synthesizes these characteristics and of finding the linear combination of the acquired ECGs, which maximizes this QI. In the application for fQRS detection two QIs are devised, one QI (mQI) for maternal ECG (mECG) and one QI (fQI) for fetal ECG (fECG). The method is completely unsupervised and based on the following steps: signal pre-processing; maternal QRS-enhanced signal extraction by finding the linear combination that maximize the mQI; detection of maternal QRSs; mECG component approximation and canceling by weighted Singular Value Decomposition (SVD); fQRS-enhanced signal extraction by finding the linear combination that maximize the fQI and fQRS detection. The proposed method was compared with our previously developed Independent Component Analysis (ICA) based method as well as with simple mECG canceling and simple ICA methods. The comparison was carried out by evaluating the performances of the procedures in fQRS detection. The new method outperformed the results of the other approaches on the annotated open set of the Computing in Cardiology Challenge 2013 database. The proposed method seems to be promising for its implementation on portable device and for use in self-monitoring of fetal health in pregnant women.

摘要

本文提出了一种用于多通道心电图中QRS波群检测的新方法,并介绍了其在从孕妇腹部导联采集的信号中检测胎儿QRS波群(fQRS)的应用。该方法利用了QRS波群的伪周期性和时间形态特征,包括设计一个综合这些特征的质量指标(QI),以及找到所采集心电图的线性组合,以使该QI最大化。在fQRS检测的应用中,设计了两个QI,一个用于母亲心电图(mECG)的QI(mQI)和一个用于胎儿心电图(fECG)的QI(fQI)。该方法完全无监督,基于以下步骤:信号预处理;通过找到使mQI最大化的线性组合来提取母亲QRS增强信号;检测母亲QRS波群;通过加权奇异值分解(SVD)近似和消除mECG分量;通过找到使fQI最大化的线性组合来提取fQRS增强信号并进行fQRS检测。将所提出的方法与我们之前开发的基于独立成分分析(ICA)的方法以及简单的mECG消除和简单ICA方法进行了比较。通过评估这些程序在fQRS检测中的性能来进行比较。在2013年心脏病学计算挑战赛数据库的带注释开放集中,新方法的结果优于其他方法。所提出的方法在便携式设备上的实现以及用于孕妇胎儿健康自我监测方面似乎很有前景。

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