Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), National Jiangsu Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China.
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
Small. 2016 Jun;12(21):2913-20. doi: 10.1002/smll.201600041. Epub 2016 Apr 23.
Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K(+) ). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.
在局域表面等离激元共振纳米技术的推动下，提出了一种基于单个 Au@Ag 核壳纳米立方体（Au@Ag NC）的简单灵敏的等离子体适体纳米传感器（nanoaptasensor），用于实时监测 G-四链体结构的形成过程和钾离子（K(+)）的无标记分析。特别是，热力学参数的分析表明，在端粒 DNA 序列的顺序折叠过程中存在两种结合状态，并伴随着自由能（ΔG）的显著变化。这种纳米适体传感器在监测 G-四链体结构开关的动态过程方面具有广阔的应用前景。
