Platt D
Aktuelle Gerontol. 1978 Jun;8(6):297-301.
Molecular and supramolecular mechanisms of ageing involve biochemical, physiological and morphological alterations of organs. Furthermore physiological disturbances are superimposed by pathological mechanisms of ageing. As a result the number of diseases in higher age increases as well as there are a lot of therapeutical problems. The following paper tries to reveal that physiological and pathological changes of different organs (heart, kidney, lung, brain) influence the therapy of older man. The results demonstrate that it is necessary to stimulate the research of pharmacodynamics and kinetics in the higher age.
衰老的分子和超分子机制涉及器官的生化、生理和形态学改变。此外，生理紊乱还叠加了衰老的病理机制。因此，高龄人群中的疾病数量增加，同时也存在许多治疗问题。以下论文试图揭示不同器官（心脏、肾脏、肺、脑）的生理和病理变化如何影响老年男性的治疗。结果表明，有必要推动对高龄人群药效学和药代动力学的研究。
