Department of Physiology, School of Medicine, Universidad Centro-Occidental "Lisandro Alvarado" and Cardio-metabolic Unit 7, Barquisimeto, Venezuela; Department of Physiology, School of Medicine, University of Panamá, Panama City, Panamá.
The Andes Clinic of Cardio-Metabolic Studies, Mérida, Venezuela.
Ann Glob Health. 2015 Nov-Dec;81(6):776-91. doi: 10.1016/j.aogh.2015.11.002.
The incidence of type 2 diabetes (T2D) and its economic burden have increased in Venezuela, posing difficult challenges in a country already in great turmoil.
The aim of this study was to review the prevalence, causes, prevention, management, health policies, and challenges for successful management of diabetes and its complications in Venezuela.
A comprehensive literature review spanning 1960 to 2015 was performed. Literature not indexed also was reviewed. The weighted prevalence of diabetes and prediabetes was estimated from published regional and subnational population-based studies. Diabetes care strategies were analyzed.
In Venezuela, the weighted prevalence of diabetes was 7.7% and prediabetes was 11.2%. Diabetes was the fifth leading cause of death (7.1%) in 2012 with the mortality rate increasing 7% per year from 1990 to 2012. In 2012, cardiovascular disease and diabetes together were the leading cause of disability-adjusted life years.T2D drivers are genetic, epigenetic, and lifestyle, including unhealthy dietary patterns and physical inactivity. Obesity, insulin resistance, and metabolic syndrome are present at lower cutoffs for body mass index, homeostatic model assessment, and visceral or ectopic fat, respectively. Institutional programs for early detection and/or prevention of T2D have not been established. Most patients with diabetes (∼87%) are cared for in public facilities in a fragmented health system. Local clinical practice guidelines are available, but implementation is suboptimal and supporting information is limited.
Strategies to improve diabetes care in Venezuela include enhancing resources, reducing costs, improving education, implementing screening (using Latin America Finnish Diabetes Risk Score), promoting diabetes care units, avoiding insulin levels as diagnostic tool, correct use of oral glucose tolerance testing and metformin as first-line T2D treatment, and reducing health system fragmentation. Use of the Venezuelan adaptation of the transcultural Diabetes Nutrition Algorithm for lifestyle recommendations and the Latin American Diabetes Association guidelines for pharmacologic interventions can assist primary care physicians in diabetes management.
委内瑞拉 2 型糖尿病(T2D)的发病率及其经济负担不断增加,这给一个本已陷入巨大动荡的国家带来了严峻挑战。
本研究旨在回顾委内瑞拉糖尿病及其并发症的流行情况、病因、预防、管理、卫生政策和成功管理面临的挑战。
对 1960 年至 2015 年的文献进行了全面综述,还对未被索引的文献进行了综述。根据已发表的区域性和国家级人群研究,估算糖尿病和糖尿病前期的加权患病率。分析了糖尿病护理策略。
委内瑞拉的糖尿病加权患病率为 7.7%,糖尿病前期为 11.2%。2012 年,糖尿病是第五大死因(7.1%),1990 年至 2012 年期间,死亡率每年增加 7%。2012 年,心血管疾病和糖尿病一起成为导致残疾调整生命年(DALY)损失的主要原因。T2D 的驱动因素包括遗传、表观遗传和生活方式,包括不健康的饮食模式和缺乏身体活动。肥胖、胰岛素抵抗和代谢综合征的体质量指数、稳态模型评估和内脏或异位脂肪的截断值分别较低。尚未建立早期发现和/或预防 T2D 的机构方案。大多数糖尿病患者(约 87%)在公共设施中接受治疗,治疗分散在整个卫生系统中。当地有临床实践指南,但实施情况不佳,且支持信息有限。
改善委内瑞拉糖尿病护理的策略包括增加资源、降低成本、加强教育、实施筛查(使用拉丁美洲芬兰糖尿病风险评分)、推广糖尿病护理单位、避免将胰岛素水平作为诊断工具、正确使用口服葡萄糖耐量试验和二甲双胍作为 T2D 的一线治疗方法,以及减少卫生系统碎片化。使用委内瑞拉改编的跨文化糖尿病营养算法进行生活方式建议,以及拉丁美洲糖尿病协会的药物干预指南,可以帮助初级保健医生进行糖尿病管理。