Department of Physiological Sciences, Universidad de Oriente, Ciudad Bolívar, Venezuela.
Department of Physiological Sciences, Universidad de Oriente, Ciudad Bolívar, Venezuela,
Med Princ Pract. 2019;28(4):324-332. doi: 10.1159/000499468. Epub 2019 Mar 11.
The Finnish Diabetes Risk Score (FINDRISC) includes anthropometric, metabolic, and lifestyle factors that predict type 2 diabetes mellitus. The objective of this study was to evaluate the FINDRISC modified for Latin America (LA-FINDRISC) as a screening tool for persons with impaired glucose metabolism in Ciudad Bolívar, Venezuela.
Subjects aged between 18 and 70 years of both sexes without known diabetes were invited to participate. After informed consent, they were screened with the LA-FINDRISC questionnaire and then given an oral glucose tolerance test, using the American Diabetes Association criteria for diagnosis. To obtain the cutoff point of LA-FINDRISC for predicting impaired glucose regulation, a receiver operating characteristic curve was constructed.
A total of 200 subjects were evaluated, 64.5% female, with a mean age of 35.20 ± 13.84 years. Of these, 158 (79%) did not present with carbohydrate metabolism disorder, while 42 (21%) did. Age (p = 0.0001), body mass index (p = 0.011), and waist circumference (p = 0.031) were significantly higher in subjects with impaired glucose regulation when compared to those without it. There were a significantly greater number of sedentary (p = 0.039) and hypertensive subjects (p = 0.0001), as well as those with a history of glucose >100 mg/dL (p = 0.0001), in the impaired glucose metabolism group. A cutoff LA-FINDRISC of 14 points predicted a high risk of impaired glucose regulation with a sensitivity of 45.2% and a specificity of 89.9%.
A LA-FINDRISC >14 points had low sensitivity but high specificity for predicting carbohydrate metabolism disorders in this group of patients from Ciudad Bolívar.
芬兰糖尿病风险评分（FINDRISC）包含预测 2 型糖尿病的人体测量、代谢和生活方式因素。本研究旨在评估针对拉丁美洲（LA-FINDRISC）的改良 FINDRISC 作为委内瑞拉玻利瓦尔城葡萄糖代谢受损人群的筛查工具。
邀请年龄在 18 至 70 岁之间的男女无已知糖尿病的受试者参加。知情同意后，他们接受了 LA-FINDRISC 问卷筛查，然后根据美国糖尿病协会的诊断标准进行口服葡萄糖耐量试验。为了获得 LA-FINDRISC 预测葡萄糖调节受损的截断值，构建了受试者工作特征曲线。
共评估了 200 名受试者，其中 64.5%为女性，平均年龄为 35.20±13.84 岁。其中，158 名（79%）受试者未出现碳水化合物代谢紊乱，而 42 名（21%）受试者出现了该情况。与无葡萄糖调节受损的受试者相比，葡萄糖调节受损的受试者年龄（p=0.0001）、体重指数（p=0.011）和腰围（p=0.031）显著更高。葡萄糖>100mg/dL 史（p=0.0001）的受试者，静息（p=0.039）和高血压（p=0.0001）的受试者比例显著更高。LA-FINDRISC 切点为 14 分，预测葡萄糖调节受损的高风险，其灵敏度为 45.2%，特异性为 89.9%。
在玻利瓦尔城的这组患者中，LA-FINDRISC>14 分预测碳水化合物代谢紊乱的灵敏度低，但特异性高。
