Gilles C, Ryckaert P, De Mol J, de Maertelaere V, Mendlewicz J
Psychiatric Department, Erasme University Hospital, Brussels, Belgium.
Psychiatry Res. 1989 Mar;27(3):277-86. doi: 10.1016/0165-1781(89)90143-1.
This study was undertaken to assess the value of growth hormone (GH) response to clonidine as a tool in the differential diagnosis between depression and dementia. This response is known to be blunted in depression, and neurochemical changes observed in senile dementia of the Alzheimer type (SDAT) could lead to an up-regulation of GH secretion. No difference was observed between GH response in depressed and demented patients. Together with studies on GH basal secretion in Alzheimer's disease, this finding suggests that the final consequence of SDAT-related changes in an accentuation of the effects of aging on GH reactivity.
本研究旨在评估生长激素（GH）对可乐定的反应作为抑郁症和痴呆症鉴别诊断工具的价值。已知这种反应在抑郁症中会减弱，而在阿尔茨海默型老年痴呆症（SDAT）中观察到的神经化学变化可能导致GH分泌上调。抑郁症患者和痴呆症患者的GH反应未观察到差异。结合对阿尔茨海默病中GH基础分泌的研究，这一发现表明SDAT相关变化的最终结果是衰老对GH反应性影响的加剧。
