Krishnan K R, Manepalli A N, Ritchie J C, Rayasam K, Melville M L, Daughtry G, Thorner M O, Rivier J E, Vale W W, Nemeroff C B
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
Am J Psychiatry. 1988 Jan;145(1):90-2. doi: 10.1176/ajp.145.1.90.
The authors administered the growth hormone-releasing factor (GRF) stimulation test to 19 patients with major depression and 19 age- and sex-matched control subjects to test the hypothesis that a blunted growth hormone (GH) response to clonidine reflects a central alpha 2-adrenergic receptor subsensitivity in depression. GH response to GRF was significantly higher in patients with depression than in control subjects. This group difference was mainly attributable to three of the 19 depressed patients who exhibited markedly high GH responses to GRF. These results suggest that the blunted GH response to clonidine seen in patients with depression is not due to a pituitary defect in GH secretion.
作者对19例重度抑郁症患者和19例年龄及性别匹配的对照受试者进行了生长激素释放因子（GRF）刺激试验，以检验以下假设：抑郁症患者对可乐定的生长激素（GH）反应迟钝反映了中枢α2-肾上腺素能受体敏感性降低。抑郁症患者对GRF的GH反应显著高于对照受试者。这种组间差异主要归因于19例抑郁症患者中有3例对GRF表现出明显高的GH反应。这些结果表明，抑郁症患者中观察到的对可乐定的GH反应迟钝并非由于GH分泌的垂体缺陷。
