Galvao F H, Araki J, Seid V E, Waisberg D R, Traldi M C, Naito M, Araujo B C, Lanchotte C, Chaib E, D'Albuquerque L A C
Department of Gastroenterology, University of São Paulo, São Paulo, Brazil.
Department of Plastic Surgery, University of Tokyo, Tokyo, Japan.
Transplant Proc. 2016 Mar;48(2):497-8. doi: 10.1016/j.transproceed.2015.10.082.
Anorectal dysfunction resulting in fecal incontinence or permanent colostomy is a current public health concern that strongly impairs patient quality of life. Present treatment options for this complex disease are expensive and usually ineffective. Anorectal transplantation is the logical treatment for fecal incontinence and permanent colostomy. This procedure has been clinically effective in a few cases reported in the medical literature. Furthermore, experiments in rats, pigs, and dogs have shown promising results, with functional recovery of the graft. In this article we describe the scientific evidence that anorectal transplantation may be an important option for treating anorectal dysfunction.
导致大便失禁或永久性结肠造口术的肛肠功能障碍是当前的一个公共卫生问题，严重损害患者的生活质量。针对这种复杂疾病目前的治疗选择昂贵且通常无效。肛肠移植是治疗大便失禁和永久性结肠造口术的合理疗法。该手术在医学文献报道的少数病例中已显示出临床疗效。此外，在大鼠、猪和狗身上进行的实验也显示出了有前景的结果，移植组织实现了功能恢复。在本文中，我们阐述了肛肠移植可能是治疗肛肠功能障碍的重要选择的科学证据。
