Bagheri Mahsa, Mohammadi Marzieh, Steele Terry Wj, Ramezani Mohammad
Shariati Hospital, Mashhad University of Medical Sciences, Mashhad, PO Box 935189-9983, Iran.
Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, PO Box 91775-1365, Iran.
Nanomedicine (Lond). 2016 May;11(10):1309-26. doi: 10.2217/nnm-2015-0007.
The advent of percutaneous coronary intervention and intravascular stents has revolutionized the field of interventional cardiology. Nonetheless, in-stent restenosis, inflammation and late-stent thrombosis are the major obstacles with currently available stents. In order to enhance the hemocompatibility of stents, advances in the field of nanotechnology allow novel designs of nanoparticles and biomaterials toward localized drug/gene carriers or stent scaffolds. The current review focuses on promising polymers used in the fabrication of newer generations of stents with a short synopsis on atherosclerosis and current commercialized stents, nanotechnology's impact on stent development and recent advancements in stent biomaterials is discussed in context.
经皮冠状动脉介入治疗和血管内支架的出现彻底改变了介入心脏病学领域。尽管如此，支架内再狭窄、炎症和晚期支架血栓形成是现有支架的主要障碍。为了提高支架的血液相容性，纳米技术领域的进展使得能够设计新型纳米颗粒和生物材料，用于局部药物/基因载体或支架支架。本综述重点关注用于制造新一代支架的有前景的聚合物，并简要介绍动脉粥样硬化和当前商业化支架，探讨了纳米技术对支架开发的影响以及支架生物材料的最新进展。
