Ishii Akira, Tanaka Masaaki, Watanabe Yasuyoshi
Department of Physiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
RIKEN, Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Hyogo 650-0047, Japan.
Sci Rep. 2016 Apr 26;6:25097. doi: 10.1038/srep25097.
Fatigue is a major contributor to workplace accidents, morbidity, and mortality. To prevent the disruption of homeostasis and to concurrently accomplish an assigned workload, it is essential to control the level of workload based on the subjective estimation of the level of fatigue that will be experienced in the near future. In this study, we aimed to clarify the neural mechanisms related to predicting subjective levels of fatigue that would be experienced 60 min later, using magnetoencephalography. Sixteen healthy male volunteers participated in this study. In relation to the prediction, a decrease of alpha band power in the right Brodmann's area (BA) 40 and BA 9 at 1200 to 1350 ms and that in the right BA 9 at 1350 to 1500 ms, and a decrease of gamma band power in the right BA 10 at 1500 to 1650 ms were observed. In addition, the decreased level of alpha band power in BA 9 at 1200 to 1350 ms was positively associated with the daily level of fatigue. These findings may help increase our understanding of the neural mechanisms activated to indicate the need to take a rest based on the prediction of the subjective fatigue in the future.
疲劳是导致工作场所事故、发病和死亡的主要因素。为防止体内平衡被打破并同时完成分配的工作量，根据对不久后将经历的疲劳程度的主观估计来控制工作量水平至关重要。在本研究中，我们旨在利用脑磁图来阐明与预测60分钟后将经历的主观疲劳水平相关的神经机制。16名健康男性志愿者参与了本研究。关于预测，观察到在1200至1350毫秒时右侧布罗德曼区（BA）40和BA 9以及在1350至1500毫秒时右侧BA 9的α波段功率下降，以及在1500至1650毫秒时右侧BA 10的γ波段功率下降。此外，在1200至1350毫秒时BA 9的α波段功率下降水平与每日疲劳程度呈正相关。这些发现可能有助于增进我们对基于未来主观疲劳预测而激活的指示需要休息的神经机制的理解。
