Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
RIKEN, Center for Biosystems Dynamics Research, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Sci Rep. 2019 Mar 8;9(1):4000. doi: 10.1038/s41598-019-40605-7.
Fatigue is a health problem prevalent in modern societies. Fatigue sensation plays an important role as a biological alarm urging rest to maintain homeostasis, and clarifying the neural mechanisms related to fatigue sensations by which we decide to engage in rest is therefore essential. This study enrolled healthy male volunteers and showed that the decrease in alpha-band power as assessed by magnetoencephalography of the left Brodmann's area (BA) 6 before perception of fatigue when a button-press based on the level of fatigue was required was smaller than that before perception of the intention to move when a voluntary button-press was required. In addition, the decrease of alpha-band power in the left BA 6 before the perception of fatigue was not altered compared with that in the right BA 6 when a button-press based on the level of fatigue was required. These results suggest that the button-press based on the perception of fatigue is not prepared before the perception of fatigue. These findings will advance the understanding of the neural mechanisms related to subjective feelings such as fatigue sensation.
疲劳是现代社会中普遍存在的健康问题。疲劳感作为一种生物警报，起着敦促休息以维持体内平衡的重要作用，因此，阐明与疲劳感相关的神经机制，以便我们决定进行休息是至关重要的。本研究招募了健康的男性志愿者，结果表明，当需要根据疲劳程度进行基于按钮的按压时，与需要进行自愿性按钮按压以感知运动意图之前相比，左布罗德曼区（BA）6 的脑磁图评估的 alpha 波段功率下降较小。此外，当需要根据疲劳程度进行基于按钮的按压时，左 BA 6 的 alpha 波段功率下降与右 BA 6 相比没有改变。这些结果表明，在感知疲劳之前，基于疲劳感知的按钮按压并没有准备好。这些发现将有助于理解与疲劳感等主观感觉相关的神经机制。
