Miyazaki Daigo, Nakamura Akinori, Hineno Akiyo, Kobayashi Chinatsu, Kinoshita Tomomi, Yoshida Kunihiro, Ikeda Shu-Ichi
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan.
Intractable Disease Care Center, Shinshu University Hospital, Asahi 3-1-1, Matsumoto, 390-8621, Japan.
Neurol Sci. 2016 Aug;37(8):1277-81. doi: 10.1007/s10072-016-2582-1. Epub 2016 Apr 25.
Heat-shock proteins (HSPs) have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study, we aimed to examine whether the serum levels of HSPs (HSP27, HSP70, and HSP90) are altered in patients with ALS. We included 58 patients diagnosed with ALS and 85 control individuals. Serum HSP levels of patients and controls were determined using enzyme-linked immunosorbent assay. The serum levels of HSP70 and HSP90 were significantly higher in patients than in controls. In contrast, serum levels of HSP27 did not differ significantly between the patient and control groups. Moreover, serum levels of HSP70 and HSP90 in patients remained high throughout the duration of the disease. Taken together, our findings suggest that HSPs might have a role in ALS progression throughout the course of the disease. Further studies are needed to clarify the role of HSPs in the pathogenesis of ALS.
热休克蛋白（HSPs）与肌萎缩侧索硬化症（ALS）的发病机制有关。在本研究中，我们旨在检测ALS患者血清中热休克蛋白（HSP27、HSP70和HSP90）水平是否发生改变。我们纳入了58例诊断为ALS的患者和85名对照个体。采用酶联免疫吸附测定法测定患者和对照者的血清热休克蛋白水平。患者血清中HSP70和HSP90水平显著高于对照者。相比之下，患者组和对照组之间血清HSP27水平无显著差异。此外，患者血清中HSP70和HSP90水平在疾病全过程中均保持较高水平。综上所述，我们的研究结果表明，热休克蛋白可能在ALS疾病全过程进展中发挥作用。需要进一步研究以阐明热休克蛋白在ALS发病机制中的作用。
