[唾液腺肿瘤中热休克蛋白的表达。HSP27、HSP70、HSP90和HSP110的免疫组织化学研究：附50例报告]
[Expression of heat shock proteins in salivary gland tumors. Immunohistochemical study of HSP27, HSP70, HSP90, and HSP110: apropos of 50 cases].
作者信息
Vanmuylder N, Evrard L, Daelemans P, Van Reck J, Dourov N
机构信息
Laboratoire d'Anatomie Pathologique et de Microscopie Electronique, Université Libre de Bruxelles, route de Lennik, 1070 Bruxelles.
出版信息
Ann Pathol. 2000 May;20(3):190-5.
Heat shock proteins (HSPs) are known to be increased in response to biological stress. Recently some authors described their presence in tumors. Our immunohistochemical investigations revealed the expression of HSP27, HSP70, HSP90 and HSP110 in most of benign tumors of salivary glands (33 cases). In the malignant tumors, the reaction was immunopositive for HSP70 and HSP90 in 13/17 cases; but HSP27 and HSP110 were only expressed in 5/17 cases. In conclusion HSPs were expressed less in malignant than in benign cells. These results suggest that the loss of some HSPs may be a possible sign of malignancy.
热休克蛋白（HSPs）已知会在生物应激反应中增加。最近，一些作者描述了它们在肿瘤中的存在。我们的免疫组织化学研究揭示了HSP27、HSP70、HSP90和HSP110在大多数涎腺良性肿瘤（33例）中的表达。在恶性肿瘤中，13/17例对HSP70和HSP90呈免疫阳性反应；但HSP27和HSP110仅在5/17例中表达。总之，HSPs在恶性细胞中的表达低于良性细胞。这些结果表明，某些HSPs的缺失可能是恶性肿瘤的一个可能迹象。
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