Mothana Ramzi, Alsaid Mansour, Khaled Jamal M, Alharbi Naiyf S, Alatar Abdulrahman, Raish Mohammad, Al-Yahya Mohammed, Rafatullah Syed, Parvez Mohammad Khalid, Ahamad Syed Rizwan
Department of Pharmacognosy and Medicinal, Aromatic & Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Pak J Pharm Sci. 2016 Mar;29(2 Suppl):671-7.
This study was designed to investigate the possible antiniciceptive, antipyretic and antimicrobial activities of the essential oil obtained from the fruits of Piper Cubeba (L.). To assess the antinociceptive and antipyretic activities, three doses (150, 300 and 600 mg/kg, i.p.) were tested in acetic acid-induced abdominal writhing, tail flick reaction and hot-plate and Brewer's yeast-induced hyperpyrexia test models in animals. Moreover, the antimicrobial activity was examined using agar diffusion method and broth micro-dilution assay for minimum inhibitory concentrations (MIC). The Piper Cubeba essential oil (PCEO) showed a marked antinociception (17, 30 and 54%) and an increase in reaction time in mice in the flick tailed and hot-plate tests. The brewer's yeast induced hyperpyrexia was decreased in a dose dependent manner. PCEO also exhibited a strong antimicrobial potential. These findings confirm the traditional analgesic indications of P. cubeba oil and provide persuasive evidence and support its use in Arab traditional medicine.
本研究旨在调查从荜澄茄（Piper Cubeba (L.)）果实中提取的挥发油可能具有的抗伤害感受、解热和抗菌活性。为评估其抗伤害感受和解热活性，在动物的醋酸诱导扭体反应、甩尾反应、热板法及啤酒酵母诱导的高热试验模型中测试了三个剂量（150、300和600 mg/kg，腹腔注射）。此外，采用琼脂扩散法和肉汤微量稀释法测定最低抑菌浓度（MIC）来检测抗菌活性。荜澄茄挥发油（PCEO）在甩尾试验和热板试验中对小鼠表现出显著的抗伤害感受作用（分别为17%、30%和54%），且反应时间增加。啤酒酵母诱导的高热呈剂量依赖性降低。PCEO还表现出强大的抗菌潜力。这些发现证实了荜澄茄油的传统止痛功效，并提供了有说服力的证据，支持其在阿拉伯传统医学中的应用。
