N-Myc 下游调节基因 2（NDRG2）在多种人类癌症中的临床和病理意义。

Clinical and pathological significance of N-Myc downstream-regulated gene 2 (NDRG2) in diverse human cancers.

机构信息

Department of Geriatrics, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an, 710032, China.

Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, China.

出版信息

Apoptosis. 2016 Jun;21(6):675-82. doi: 10.1007/s10495-016-1244-3.

DOI:10.1007/s10495-016-1244-3

PMID:27113371

Abstract

Human N-Myc downstream-regulated gene 2 (NDRG2), located at chromosome 14q11.2, has been reported to be down-regulated and associated with the progression and prognosis of diverse cancers. Collectively, previous studies suggest that NDRG2 functions as a candidate tumor-suppressor gene; thus, up-regulation of NDRG2 protein might act as a promising therapeutic strategy for malignant tumors. The aim of this review was to comprehensively present the clinical and pathological significance of NDRG2 in human cancers.

摘要

人类 N-霉酰基化天冬氨酸特异性蛋白酶 2（NDRG2）位于染色体 14q11.2，据报道其表达下调与多种癌症的进展和预后相关。综上所述，以往的研究表明 NDRG2 作为候选抑癌基因发挥作用；因此，上调 NDRG2 蛋白可能成为恶性肿瘤有前途的治疗策略。本综述的目的是全面阐述 NDRG2 在人类癌症中的临床和病理意义。