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DNA倍体、基质和核型分析在预测胃癌腹膜转移风险中的临床意义。

Clinical implications of DNA ploidy, stroma, and nucleotyping in predicting peritoneal metastasis risk for gastric cancer.

作者信息

Yuan Jingwen, Jiang Yue, Chen Fangfang, Li Tian, Zeng Zhi, Ruan Shasha, Yan Junfeng, Lu Jiatong, Li Qiang, Yuan Jingping, Tong Qiang

机构信息

Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

Colorectal Surgery Department, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.

出版信息

BMC Cancer. 2025 Jan 25;25(1):144. doi: 10.1186/s12885-025-13564-8.

DOI:10.1186/s12885-025-13564-8
PMID:39863844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11762900/
Abstract

BACKGROUND

Gastric cancer peritoneal metastasis lacks effective predictive indices. This article retrospectively explored predictive values of DNA ploidy, stroma, and nucleotyping in gastric cancer peritoneal metastasis.

METHODS

A comprehensive analysis was conducted on specimens obtained from 80 gastric cancer patients who underwent gastric resection at the Department of Gastrointestinal Surgery of Wuhan University Renmin Hospital. Tumor tissues were sectioned and stained. DNA ploidy, stroma, and nucleotyping were quantified using microscopy and digital analysis software. Data analysis was employed by Pearson Chi-square, continuous correction Chi-square, and binary logistic regression.

RESULTS

Using both univariate and multivariate analysis, pathological T stage and nucleotyping exhibited a positive correlation with peritoneal metastasis. DNA ploidy and stroma showed a positive correlation in univariate analysis. Chi-square tests demonstrated a positive correlation of DNA ploidy, stroma, and nucleotyping with peritoneal metastasis. The combined application of these three indicators displayed heightened predictive value for peritoneal metastasis. Non-diploid status, high stroma, and chromosomal heterogeneity emerged as positive factors for peritoneal metastasis in gastric cancer.

CONCLUSIONS

DNA ploidy, stroma, and nucleotyping prove to be predictive factors for peritoneal metastasis, with enhanced predictive efficacy when combined in pairs.

摘要

背景

胃癌腹膜转移缺乏有效的预测指标。本文回顾性探讨了DNA倍体、间质及核型分析在胃癌腹膜转移中的预测价值。

方法

对武汉大学人民医院胃肠外科80例行胃癌切除术患者的标本进行综合分析。将肿瘤组织切片并染色。使用显微镜及数字分析软件对DNA倍体、间质及核型进行定量分析。采用Pearson卡方检验、连续校正卡方检验及二元logistic回归进行数据分析。

结果

单因素及多因素分析显示，病理T分期及核型分析与腹膜转移呈正相关。单因素分析中DNA倍体与间质呈正相关。卡方检验显示DNA倍体、间质及核型分析与腹膜转移呈正相关。这三个指标联合应用对腹膜转移具有更高的预测价值。非二倍体状态、高间质及染色体异质性是胃癌腹膜转移的阳性因素。

结论

DNA倍体、间质及核型分析是腹膜转移的预测因素，两两联合时预测效能增强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbf/11762900/614bc6d120d0/12885_2025_13564_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbf/11762900/bf82ddaa862b/12885_2025_13564_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbf/11762900/2e808f827d4b/12885_2025_13564_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbf/11762900/614bc6d120d0/12885_2025_13564_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbf/11762900/bf82ddaa862b/12885_2025_13564_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbf/11762900/2e808f827d4b/12885_2025_13564_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbf/11762900/614bc6d120d0/12885_2025_13564_Fig3_HTML.jpg

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