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LVIS支架与Enterprise支架治疗未破裂颅内动脉瘤的比较

LVIS Stent Versus Enterprise Stent for the Treatment of Unruptured Intracranial Aneurysms.

作者信息

Ge Huijian, Lv Xianli, Yang Xinjian, He Hongwei, Jin Hengwei, Li Youxiang

机构信息

Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Beijing Engineering Research Center for Interventional Neuroradiology, Beijing, China.

Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Beijing Engineering Research Center for Interventional Neuroradiology, Beijing, China.

出版信息

World Neurosurg. 2016 Jul;91:365-70. doi: 10.1016/j.wneu.2016.04.057. Epub 2016 Apr 22.

Abstract

OBJECTIVE

This retrospective study compared clinical and angiographic outcomes between LVIS and Enterprise stents.

MATERIALS AND METHODS

From November 2014 to December 2015, total 190 patients with 208 unruptured intracranial aneurysms were coiled assisted by LVIS and Enterprise stents. Procedure-related complications, clinical outcomes, and angiographic results were analyzed retrospectively.

RESULTS

A total of 92 patients with 96 aneurysms received LVIS stents and 98 patients with 112 aneurysms were treated with Enterprise stents. Procedure-related complications occurred in 10.9% of patients (2 hemorrhagic events and 8 thromboembolic events) in the LVIS stents group whereas 16.3% (1 hemorrhage, 1 mass effect, and 14 thromboembolic events) in the Enterprise stents group. No statistical significant differences in thromboembolic (P = 0.263), hemorrhagic complications (P = 0.611), and favorable clinical outcomes (modified Rankin Scores of 0-2) (P = 0.379) were found between 2 groups. A greater initial complete or near-complete obliteration was found in the LVIS stents group compared with the Enterprise stents group (96.9% vs. 88.4%, P = 0.034). Larger aneurysm size (P = 0.048) was an independent predictor of procedure-related complications in univariate analysis.

CONCLUSIONS

Compared with Enterprise stents, LVIS stents may achieve greater complete or near-complete occlusion rate. There was no significant difference in procedural-related complications and clinical outcomes between LVIS and Enterprise stents.

摘要

目的

本回顾性研究比较了LVIS支架和Enterprise支架的临床及血管造影结果。

材料与方法

2014年11月至2015年12月,共有190例患有208个未破裂颅内动脉瘤的患者接受了LVIS和Enterprise支架辅助弹簧圈栓塞治疗。对手术相关并发症、临床结果及血管造影结果进行回顾性分析。

结果

共有92例患有96个动脉瘤的患者接受了LVIS支架治疗,98例患有112个动脉瘤的患者接受了Enterprise支架治疗。LVIS支架组手术相关并发症发生率为10.9%(2例出血事件和8例血栓栓塞事件),而Enterprise支架组为16.3%(1例出血、1例占位效应和14例血栓栓塞事件)。两组间血栓栓塞并发症(P = 0.263)、出血并发症(P = 0.611)及良好临床结局(改良Rankin评分0 - 2分)(P = 0.379)差异均无统计学意义。与Enterprise支架组相比,LVIS支架组初始完全或近乎完全闭塞率更高(96.9%对88.4%,P = 0.034)。单因素分析显示,较大的动脉瘤尺寸(P = 0.048)是手术相关并发症的独立预测因素。

结论

与Enterprise支架相比,LVIS支架可能实现更高的完全或近乎完全闭塞率。LVIS支架与Enterprise支架在手术相关并发症及临床结果方面无显著差异。

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